منابع مشابه
Paxillin brings peace to microtubules
Lipid droplets ensure their own consumption H ungry yeast cells use a clever form of recycling to ensure that they can keep consuming stored lipids, Wang et al. show. Lean times spur yeast cells to enter a quiescent state known as the stationary phase. They break down cached lipids by delivering lipid droplets to the vacuole and resort to autophagy, in which they digest a portion of their own c...
متن کاملPaxillin: adapting to change.
Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs...
متن کاملTo transitory peace ●
article looks at definitions of peace from a cultural studies perspective, suggesting that binary oppositions governing such fields as peace and war, individual and society, tradition and modernity offer few grounds for progress towards peace. The article suggests instead that the utopian principle of hope can be recruited for a culture of peace based on the surrender to difference, at a subjec...
متن کاملBardoxolone brings Nrf2-based therapies to light.
The targeted activation of nuclear factor erythroid-derived-2-like 2 (Nrf2) to alleviate symptoms of chronic kidney disease has recently garnered much attention. Unfortunately, the greatest clinical success to date, bardoxolone, failed in phase III clinical trial for unspecified safety reasons. The present letter to the editor discusses the clinical development of bardoxolone and explores poten...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2014
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2063iti3